Oncology / Haematology

A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Olaparib Alone or in Combination With Bevacizumab Compared to Bevacizumab with 5-FU in Participants with Unresectable or Metastatic Colorectal Cancer who Have Not Progressed Following First-line Induction of FOLFOX With Bevacizumab

Trial Name: LYNK-003

PI: Dr Babak Tamjid

Who can take part:

• Patients with a histologically-confirmed metastatic or unresectable (Stage IV as defined by AJCC eighth edition) colorectal adenocarcinoma (NCCN 2018).
• Patients who have not progressed (ie, achieved a SD, PR, or CR) after a first-line induction course of at least 6 cycles of FOLFOX + bevacizumab as first-line therapy
• Patients who have experienced unacceptable toxicity to oxaliplatin

Exclusion criteria:

• Patients with known hypersensitivity to the components and/or excipients in bevacizumab, 5-FU, or olaparib.
• Patients with known active CNS metastases and/or carcinomatous meningitis.
• Patients with an active infection requiring systemic therapy

For further information please contact Sally Heath – 03 9784 7290

Trial Phase

Non-drug Phase 1 Phase 2 Phase 3 Phase 4