Oncology / Haematology

Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Locally Advanced Rectal Cancer: A Multicentre Randomised Study (DYNAMIC-RECTAL). Randomised multi-centre biomarker-driven adjuvant treatment study. (Trial Phase 2/3)

Trial Name: DYNAMIC-Rectal  PI: Dr Zee Wan Wong

Who can take part:

  • Patients with locally advanced rectal adenocarcinoma (Pre-treatment staging: cT3-4N0 or cTanyN1-2 by MRI, or endorectal ultrasound if MRI is contraindicated) treated with curative intent.
  • Patients treated with pre-operative long course fluoropyrimidine-based chemo-radiation and TME (total mesorectal excision) type surgery with negative (R0) resection margins.


Exclusion criteria:

  • Has a history of another primary cancer within the last 3 years, with the exception of nonmelanomatous skin cancer and carcinoma in situ.
  • Patients with multiple primary colorectal cancers

For further information please contact Nathan – 03 9784 8562 

Trial Phase

Non-drug Phase 1 Phase 2 Phase 3 Phase 4